Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine.
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منابع مشابه
Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine.
The value of determining the slope of the histamine dose-response curve, in addition to the histamine provocation concentration producing a 20% reduction in FEV1 (PC20-FEV1), was assessed by analysis of histamine dose-response curves in 40 patients selected as having a wide range of increased non-specific bronchial responsiveness to inhaled histamine. The histamine dose-response curves were fou...
متن کاملEffect of pH on bronchial response to inhaled histamine.
In order to investigate the effect of pH on bronchial responsiveness to inhaled histamine, 15 subjects with non-specific bronchial hyperreactivity performed two histamine inhalation tests, one with unbuffered, and the other with buffered histamine acid phosphate solutions. The unbuffered histamine solutions were prepared with 0.9% sterile saline and had a pH range from 4.3 to 7.3, while the buf...
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BACKGROUND Bronchoconstriction has developed after inhalation of lipopolysaccharide in a dose of 20 micrograms in asthmatic patients and of 200 micrograms in normal subjects. This study set out to determine whether the bronchial response to lipopolysaccharide was related to non-specific bronchial responsiveness and atopy. METHODS Sixteen subjects with a fall in specific airway conductance of ...
متن کاملEffects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects.
The underlying mechanisms of bronchial obstruction in asthma are complex. Both bronchospasm and bronchial oedema are thought to play pivotal roles in asthma, but their respective importance in a given asthmatic individual is unknown. To address this question, we assessed the effects of pretreatment with inhaled methoxamine, a potent alpha 1-adrenoceptor agonist, on bronchial response to inhaled...
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Bronchial responses to inhaled histamine significantly increased on the 2nd day and the 7th day after influenza virus vaccination in monkeys. Bronchial responses to inhaled methacholine also significantly increased on the 14th day and the 21st day after the vaccination.
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ژورنال
عنوان ژورنال: Thorax
سال: 1983
ISSN: 0040-6376
DOI: 10.1136/thx.38.1.55